Neuron Malfunction

Things don’t always work as well as was suggested in the video.

Things that can go wrong include:

· The initial synthesis and production of the neurotransmitting chemical may be inhibited, thus little neurotransmitter is available for release.

· Certain biologically based disorders or drugs may either facilitate or inhibit the release of neurotransmitters by the presynaptic bouton.

· Nerve cells, like good Austinites, like to recycle. Neurotransmitters already released are reabsorbed into the presynaptic cell (a process known as re-uptake).

· On the surface of pre- and postsynaptic cells are various types of inhibitory receptors. These tend to act as a brake and reduce the sensitivity of the nerve cell.

· Excessive enzymatic activity may abnormally deplete neurotransmitters.

Pharmacological Treatment

Stimulants – facilitate the release of neurotransmitters in the presynaptic bouton.

Antidepressants – prevent the reuptake of neurotransmitters.

Antipsychotics – inhibit dopamine receptors.