MLAB 2321 Molecular Diagnostics for Clinical Laboratory Science

Unit 16 Assignments - Molecular Oncology

  1. Molecular Oncology Test Assignment - Read the following instructions CAREFULLY:
    1. Find ONE article about a cancer you have interest in which is written at an introductory level, ie, your classmates and I will understand it. If the URL is really long copy/paste it into and it will make a short one for you. Select an article that is relatively short. The article MUST be from a respectable source, ie, journal, professional website, etc. If several of you have the same cancer, do not worry, just make sure you pick a different article to post and that your multiple choice questions are totally different. NOTE: If you find an article through an ACC database save it to your hard drive and upload it with your post. The article must include:
      a. A general description of the cancer.
      b. Marker(s) used for detection.
      c. Test methodologies used to detect the marker(s).
      d. Clinical significance of the markers in diagnosis and prognosis.
    2. Write two multiple choice questions addressing 2b, 2c and/or 2d and include those in your post, ie, the same post that will have the url of your article. I will select one question from each student for the next exam. Be sure that you include the name of your cancer in the question. For example, “In the diagnosis of breast cancer the…”. Do NOT provide the correct answer.
    3. When you post to BlackBoard your subject line will be the name of your cancer.
    4. Be sure that you are able to answer each question. If you don't understand the question write the author for clarification. I have made this posting editable, meaning if you wish to change wording you may do so. If you do edit your post be sure to include the revision date so I will know there has been a change. For example, "revised May 11 to clarify question 2". I WILL SELECT ONE QUESTION FROM EACH STUDENT FOR EXAM 4.
    5. Post to Discussion Board by stated due date.
  2. Review Microarrays for Cancer Diagnosis and Classification
  3. Review H.R. 493: Genetic Information Nondiscrimination Act of 2007
  4. Visit the Health Vault Web site
  5. Site of interest: General Characteristics of Cancers - very nice graphics
  6. Controversy and Moral Dilemnas in Oncology Testing
    • Review the presentation, "Genetics of Oncology". The end of the presentation covers some of the controversies in the testing performed, what it means to the individual being tested and potential consequences for insurance or societal purposes.
    • Skim through the draft report U.S. System of Oversight of Genetic Testing: from the The Secretary's Advisory Committee on Genetic Testing web site. It brings up issues important to all of us.
    • After reviewing the presentation write a 150 word post about your thoughts and feelings about one or more of the controversial issues brought up in the presentation. NOTE: I would encourage you to write your post in a word processor, perform a word count, spell check and grammar check, then copy paste it into your post here in the Discussion Board.
    • Post to Discussion Board and respond to classmate by stated due dates.
  7. Visit HER2 Testing options - nice graphis for IHC and FISH
  8. Chromogenic in situ Hybridization (CISH) Overview
  9. Do a Google search for "oncogene", click on "images". Click on some of the sites.
  10. IMPORTANT: Refer to the "Notes" page of this unit for instructions on submitting your question for the exam.


Bermuda triangle? Disease (cancer) is a result of the interaction between genes, age, and the environment.


Last Update: April 22, 2012
Web Author: Terry Kotrla, MS, MT(ASCP)BB
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